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Sunday 01 August 2004

A three-way comparative study on the efficacy of twin sol to gel systems and marketed eye drops of pefloxacin mesylate.

By: Sultana Y, Jha MC, Ali A, Aqil M.

J Ocul Pharmacol Ther 2004 Aug;20(4):363-71

The authors compare the efficacy of sol to gel systems and marketed eye drops of Pefloxacin mesylate (PM) in the patients with bacterial conjunctivitis. It was an open, comparative, 3-treatment, randomized, parallel study. Formulations were tested on 15 patients with bacterial conjunctivitis. Each formulation was tested on 5 patients. Patients receiving marketed eye drops were instructed to use 2 drops, 4 times a day for 7 days. Patients receiving sol to gel were instructed to use 1 drop every 12 hours for 7 days. Pharmacodynamic parameters, based on a scale of rating, were used to assess the improvement in conjunctivitis on treatment with formulations. Conjunctival swabs were taken from eyes of patients, and viable counts were performed at days 0, 3, 5, and 7. Statistical analysis of the pharmacodynamic data indicated that both sol to gel systems used were more effective than marketed eye drops in the treatment of bacterial conjunctivitis. Results of the viable count revealed that a faster reduction in the number of colony-forming units (cfu) were obtained with both sol to gel systems, compared to marketed eye drops. It can be concluded that both sol to gel systems were superior to marketed eye drops in the treatment of bacterial conjunctivitis.

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